WebRRM2-specic inhibitors such as hydroxyurea or the more potent compound triapine (alias 3-AP) [9]. 6, ... Tumour growth on time course and h Tumour weight at the experimental endpoint. Arrows indicate treatment start. Values were normalized to Dox (–). Horizontal bars represent means and whiskers SEM. FC, fold change. P‑values were WebKey features and details Mouse monoclonal [1E1] to RRM2 Suitable for: WB, IHC-P, ICC/IF, Flow Cyt Reacts with: Human Isotype: IgG1 You may also be …
Recombinant Human RRM2 protein (ab99137) Abcam
WebJul 7, 2024 · The RRM2 mRNA levels were significantly upregulated by 2.2–5.6-fold in cancerous vs. normal tissues, while the mRNA levels of RRM1 and RRM2B were changed … WebNov 18, 2024 · With an area under the curve (AUC) > 0.8 as the standard, 2 genes were screened, namely CKS2 and RRM2. Further immune infiltration analysis showed that M2 macrophages were involved in the pathogenesis of vitiligo, whereas CKS2 and RRM2 were both related to M2 macrophages. parnorpine
Recombinant Human RRM2 protein (ab99137) Abcam
WebSep 9, 2024 · 1. Introduction. Since the elucidation of the molecular mechanisms of several diseases along with the discovery of nucleic acid structure, the replacement of defective genes with functional versions has been considered as a new therapeutic paradigm called “gene therapy” [1,2].Gene therapy is carried out by expression constructs in order to … WebMar 21, 2024 · RRM2 (Ribonucleotide Reductase Regulatory Subunit M2) is a Protein Coding gene. Diseases associated with RRM2 include Diamond-Blackfan Anemia 20 and Choriocarcinoma. Among its related pathways are pyrimidine deoxyribonucleotides … Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis … Molecular mass: 13903 Da Protein existence level: PE1 Quaternary structure: … ABCB1 (ATP Binding Cassette Subfamily B Member 1) is a Protein Coding gene. … RBMX (RNA Binding Motif Protein X-Linked) is a Protein Coding gene. Diseases … Ataxia-telangiectasia (A-T) is a recessive disorder resulting from germline … CFTR (CF Transmembrane Conductance Regulator) is a Protein Coding gene. … Size: 882 amino acids Molecular mass: 97456 Da Protein existence level: PE1 … MAPK1 (Mitogen-Activated Protein Kinase 1) is a Protein Coding gene. Diseases … NTRK1 (Neurotrophic Receptor Tyrosine Kinase 1) is a Protein Coding gene. … HMGB1 (High Mobility Group Box 1) is a Protein Coding gene. Diseases … WebJul 13, 2024 · RRM2 is the catalytic component of the RNR enzyme and is essential for the maintenance of deoxynucleotide triphosphate (dNTP) pool homeostasis required for DNA replication and repair. Synthesis of RRM2 protein is regulated in a cell cycle–dependent fashion, increasing to maximal levels during S phase of the cell cycle ( 10 – 12 ). parnor galletitas