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Rrm2 molecular weight

WebRRM2-specic inhibitors such as hydroxyurea or the more potent compound triapine (alias 3-AP) [9]. 6, ... Tumour growth on time course and h Tumour weight at the experimental endpoint. Arrows indicate treatment start. Values were normalized to Dox (–). Horizontal bars represent means and whiskers SEM. FC, fold change. P‑values were WebKey features and details Mouse monoclonal [1E1] to RRM2 Suitable for: WB, IHC-P, ICC/IF, Flow Cyt Reacts with: Human Isotype: IgG1 You may also be …

Recombinant Human RRM2 protein (ab99137) Abcam

WebJul 7, 2024 · The RRM2 mRNA levels were significantly upregulated by 2.2–5.6-fold in cancerous vs. normal tissues, while the mRNA levels of RRM1 and RRM2B were changed … WebNov 18, 2024 · With an area under the curve (AUC) > 0.8 as the standard, 2 genes were screened, namely CKS2 and RRM2. Further immune infiltration analysis showed that M2 macrophages were involved in the pathogenesis of vitiligo, whereas CKS2 and RRM2 were both related to M2 macrophages. parnorpine https://coyodywoodcraft.com

Recombinant Human RRM2 protein (ab99137) Abcam

WebSep 9, 2024 · 1. Introduction. Since the elucidation of the molecular mechanisms of several diseases along with the discovery of nucleic acid structure, the replacement of defective genes with functional versions has been considered as a new therapeutic paradigm called “gene therapy” [1,2].Gene therapy is carried out by expression constructs in order to … WebMar 21, 2024 · RRM2 (Ribonucleotide Reductase Regulatory Subunit M2) is a Protein Coding gene. Diseases associated with RRM2 include Diamond-Blackfan Anemia 20 and Choriocarcinoma. Among its related pathways are pyrimidine deoxyribonucleotides … Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis … Molecular mass: 13903 Da Protein existence level: PE1 Quaternary structure: … ABCB1 (ATP Binding Cassette Subfamily B Member 1) is a Protein Coding gene. … RBMX (RNA Binding Motif Protein X-Linked) is a Protein Coding gene. Diseases … Ataxia-telangiectasia (A-T) is a recessive disorder resulting from germline … CFTR (CF Transmembrane Conductance Regulator) is a Protein Coding gene. … Size: 882 amino acids Molecular mass: 97456 Da Protein existence level: PE1 … MAPK1 (Mitogen-Activated Protein Kinase 1) is a Protein Coding gene. Diseases … NTRK1 (Neurotrophic Receptor Tyrosine Kinase 1) is a Protein Coding gene. … HMGB1 (High Mobility Group Box 1) is a Protein Coding gene. Diseases … WebJul 13, 2024 · RRM2 is the catalytic component of the RNR enzyme and is essential for the maintenance of deoxynucleotide triphosphate (dNTP) pool homeostasis required for DNA replication and repair. Synthesis of RRM2 protein is regulated in a cell cycle–dependent fashion, increasing to maximal levels during S phase of the cell cycle ( 10 – 12 ). parnor galletitas

RRM2 antibody (11661-1-AP) Proteintech - ptglab

Category:BRCA1-regulated RRM2 expression protects glioblastoma cells

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Rrm2 molecular weight

siRNA Knockdown of RRM2 Effectively Suppressed …

• Lin ZP, Belcourt MF, Cory JG, Sartorelli AC (2004). "Stable suppression of the R2 subunit of ribonucleotide reductase by R2-targeted short interference RNA sensitizes p53(-/-) HCT-116 colon cancer cells to DNA-damaging agents and ribonucleotide reductase inhibitors". J. Biol. Chem. 279 (26): 27030–8. doi:10.1074/jbc.M402056200. PMID 15096505. • Zhang K, Hu S, Wu J, et al. (2009). "Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human … WebRecombinant Human RRM2 protein (ab99137) Datasheet SDS Submit a review Submit a question $275 Product size 100 µg $275 500 µg $1,035.00 Add to basket Order now and …

Rrm2 molecular weight

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WebAug 12, 2024 · RRM2 Background Ribonucleotide reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. It is composed of 2 non-identical subunits, … WebFeb 3, 2016 · Distinct binding affinities ( Kd) of RRM1 and RRM2 to (U/T)G repeats have been estimated in the nanomolar and micromolar range, respectively 18, 19, 20. Based upon the structure of an RRM1/ssDNA...

WebJul 27, 2024 · RRM2 is highly overexpressed in EwS, correlates with poor patient outcome, and constitutes a putative therapeutic target. a Schematic description of the filtering … WebThis gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. …

WebMar 28, 2024 · PDF Background: Ribonucleotide reductase regulatory subunit M2 (RRM2) has been reported to be an oncogene in some malignant tumors, such as lung... Find, read and cite all the research you ... WebMolecular Targeting of RRM2, NF-κB, and Mutant TP53 for the Treatment of Triple-Negative Breast Cancer Doxorubicin and other anthracycline derivatives are frequently used as part …

WebSep 13, 2016 · RRM2 is rate-limiting for the conversion of NTPs into dNTPs during the S-phase of the cell cycle ( 11 ). RRM2 is highly upregulated in melanoma cells harboring mutant BRAF V600E, and high RRM2 expression correlates with worse overall survival of patients with melanoma ( 12 ).

WebJan 5, 2024 · This study was performed by investigating RRM2 protein expression in breast cancer and correlating the results with other clinicopathological variables using … オムロン ps-3s 図面WebThe encoded protein has a calculated molecular weight of 47 kDa and contains four phosphorylation sites (serine at 366 and threonine at residues 302, 362, and 389) located at the C-terminal [2]. オムロン ps3sWebsiRNA Knockdown of RRM2 Effectively Suppressed Pancreatic Tumor Growth Alone ... 2Institute of Molecular Medicine, Peking University, Beijing 100871, China; 3Suzhou Ribo Life Science Co. Ltd., Jiangsu 215300, China; 4School of Pharmacy, Hunan University of Chinese ... to body weight were also elevated significantly at 24 and 48 hr post ... オムロン ps-3s 取説Web2 days ago · According to the previous literature, among the eight PFRs, five in the molecule set A don't all inhibit ferroptosis. RRM2 and AURKA may inhibit ferroptosis, but SLC2A1, SLC7A5 and PHKG2 are doubtful [[12], [13], [14]].According to the three conditions of “up-regulation in tumor tissue”, “worse OS”, and “inhibit ferroptosis”, two PFRs named RRM2 … parn pole alpinWebFeb 28, 2009 · The human RRM2 gene specific siRNA (sc-36338) and scramble siRNA were purchased from Santa Cruz Biotechnology, Inc. (Santa Cruz, CA). 5 × 10 5 /well KB cells were cultured in six-well plates with 2-mL antibiotic-free growth medium at 37°C in a CO 2 incubator for 24 hours. siRNA duplex-Lipofectamine was prepared by 6.0 μL of 10 μmol/L … オムロン ps-3s 仕様書WebRRM2 is a new molecular marker for the diagnosis and clinical outcomes of cervical cancer. It is involved in cervical carcinogenesis and predicts poor survival. these findings suggest … オムロン ps-3s 電極棒WebMar 14, 2014 · For RRM2 and RRM2c, each GdnHCl titration sample was excited at 274 nm, and tyrosine emission spectra were collected from 280 to 400 nm at 20 or 37 °C with 5-nm slit widths. pa road classification