WebApr 10, 2024 · In a word, these results demonstrate that the pcDNA3.1(+)/CPSIT_p7 DNA vaccine has good immunogenicity and immunity protection effectiveness against C. psittaci infection in BALB/c mice, especially pulmonary infection, and provides essential practical experience and insights for the development of a DNA vaccine against chlamydial infection. WebFeb 25, 2024 · Materials and methods: BALB/c mice were divided randomly into four groups included cancer control (CC) and three other groups. The total duration of the experiment was 14 weeks, including 2 weeks of familiarization of mice with treadmills and three of 4-week periods of experiment. Tumor inoculation and formation were performed in the …
The BALB/c Mouse: Genetics and Immun…
WebIn BALB/c mice, volume density of T zone in the spleen and production of IL-2, IL-3, IL-4, IL-10, and TNF-α were much higher than in C57Bl/6 mice. However, IL-12 production in BALB/c mice was lower than in C57Bl/6 mice. C57Bl/6 mice were characterized by higher cytostatic activity of splenic NK cells. WebBALB/c (H-2d) mice bearing a mutation of the zeta-chain–associated protein, 70-kD (ZAP-70) gene spontaneously develop autoimmune arthritis with clinical, histologic, and serologic features resembling human RA.42 The disease manifests in homozygous mice at about 2 months of age. It is a symmetric chronic polyarthritis. phoebe foundation ga
IJMS Free Full-Text Protective Immunity against Chlamydia …
WebJan 15, 2024 · F1 mice have lower numbers of adults in the intestine than C57BL/6 mice. BALB/c, F1 and C57BL/6 mice were infected with 2000 iL3 s.c. in the footpad. BALB/c is an albino, laboratory-bred strain of the house mouse from which a number of common substrains are derived. Now over 200 generations from New York in 1920, BALB/c mice are distributed globally, and are among the most widely used inbred strains used in animal experimentation. WebNov 1, 2024 · 6–8 weeks old female BALB/c mice were sacrificed and excised. The mice's spleens were cut out under sterile conditions and placed in a Petri dish (diameter 35 mm) containing 2 ml of pre-cooled RPMI 1640 medium. The spleen was gently ground with a 5 ml syringe needle to extrude the cells. phoebe foster griffith