WebImidazo[1,2-a]pyridine is a well-known scaffold in many marketed drugs, such as Zolpidem, Minodronic acid, Miroprofen and DS-1 and it also serves as a broadly applied pharmacophore in drug discovery.The scaffold revoked a wave of interest when Groebke, Blackburn and Bienaymé reported independently a new three component reaction … WebThe scaffold revoked a wave of interest when Groebke, Blackburn and Bienaymé reported independently a new three component reaction resulting in compounds with the imidazo …
Chemistry – A European Journal: Vol 28, No 3 - Chemistry Europe
WebOct 10, 2015 · The reaction proceeds even when R 1−4 are bulky substituents, showing that the scope of the reaction is not limited by the trapping when compared with a traditional Ugi . ... R.K.; Singh, V. Diversity-oriented synthesis of fused-imidazole derivatives via Groebke–Blackburn–Bienayme reaction: A review. Tetrahedron 2015, 71, 183–232. WebMay 13, 2024 · To a solution of Groebke−Blackburn−Bienayme reaction adduct (1 mmol, 1 equiv.), 3,5-dimethylisoxazole-4-boronic acid pinacol ester (1.2 mmol, 1.2 equiv.), K 2 CO 3 (2.0 mmol, 2.0 equiv.) and Pd(dppf)Cl 2 ·CH 2 Cl 2 (0.08 mmol, 0.08 equiv. 8% mol), in 2 mL of 2:1 DME/H 2 O was heated under microwave irradiation at 120 °C for 40 min … fake irs call scam
Groebke‐Blackburn‐Bienaymé reaction - ResearchGate
WebKey words PD-L1 inhibitors - multicomponent reaction - Groebke−Blackburn−Bienaymé reaction WebApr 20, 2024 · Download Citation On Apr 20, 2024, V.S. Subramaniam published Groebke‐Blackburn‐Bienaymé reaction Find, read and cite all the research you need … WebMar 13, 2024 · Three nickel substituted Keggin-type polyoxometalates, α-[SiW9O37{Ni(H2O)}3]−10 (denoted as SiW9Ni3), was intercalated into Zn3Al based Layered Double Hydroxide (Zn3Al-LDH) by the selective ion ... dollywood 4th of july 2021